Lukas A. Huber. Head of Division of Cell Biology 
Medical University of Innsbruck. Website
Biocenter, Division of Cell Biology. Innrain 80 , 6020 Innsbruck
Reseach subject
Signal Transduction and Proteomics
Summary
We would like to understand how specific cell fate decisions are made by using a pool of very similar kinases within MAPK signaling pathways. We are especially interested in the role of scaffold proteins in organizing signal transduction complexes and study the spatial and temporal resolution of signaling mechanisms as well as their cytoplasmic effectors and target genes. The aim of our research is to understand the physiological function of scaffold complexes in MAPK and mTor signaling at the molecular level in cells and at the level of the entire organism. I initiated and coordinated the FP6 EU program GROWTHSTOP, the Austrian Proteomics Platform of the Austrian Genome Program (GEN-AU), a special research program in Innsbruck entitled “Cell proliferation and Cell Death in Tumors” – SFB021 of the Austrian Science Fund (FWF) and actively participate in several EU programs and also coordinate programs. Since 2009 I am also CSO of the ONCOTYROL center of personalized cancer medicine in Innsbruck, Austria and since 2012 founder and scientific director of the Austrian Drug Screening Institute (ADSI).
Publications
- Nature. 2015 Mar 26;519(7544):477-81. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. doi: 10.1038/nature14107. Epub 2015 Jan 7. PubMed PMID: 25561175; PubMed Central PMCID: PMC4376665.
- Nat Genet. 2008 Oct;40(10):1163-5. MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity. doi: 10.1038/ng.225. Epub 2008 Aug 24. PubMed PMID: 18724368.
- J Cell Biol. 2014 May 26;205(4):525-40. The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. doi: 10.1083/jcb.201310043. Epub 2014 May 19. PubMed PMID: 24841562; PubMed Central PMCID: PMC4033770.
- J Cell Biol. 2015 Nov 9;211(3):587-604. Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. doi: 10.1083/jcb.201506112. PubMed PMID: 26553929; PubMed Central PMCID: PMC4639860.
- Nat Commun. 2014 Oct 22;5:5138. LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling. doi: 10.1038/ncomms6138. PubMed PMID: 25336251; PubMed Central PMCID: PMC4220488.