Csaba Bödör. Senior research fellow, research group leader 
Semmelweis University. Website
Faculty of Medicine. 1st Department of Pathology and Experimental Cancer Research. Ulloi ut 26, Budapest 1085, Hungary
Reseach subject
Genomics of Hematological Malignancies
Summary
The main goals of our research include genomic characterization of hematological malignancies with a special focus on B-cell malignancies (follicular lymphoma and chronic lymphocytic leukaemia) and myeloproliferative neoplasms (MPN) with a view to identify novel biomarkers and therapeutic targets. We are also interested in analysis of predisposing genetic events in familial myeloid malignancies. Our research activities build on a large biobank and extensive molecular diagnostic activity generated and demonstrated by the National Oncohematology Center lead by our department and research group. More recently, we also play a central role in the Hungarian Oncogenome and Personalised Tumor Diagnostics and Therapy National Program funded by the National Research, Development and Innovation Office with a goal to establish the detailed genomic profile of the Hungarian patients with various cancer types, including breast, colon, lung and liver cancer as well as the most frequent oncohematological diseases using whole genome- and exome sequencing. We will identify the most characteristic genomic alterations for the Hungarian population and develop liquid biopsy compatible, next generation sequencing based molecular diagnostic assays. These studies will identify novel biomarkers and targets for novel targeted therapies.
Publications
- Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutatet pedigree. European Journal of Human Genetics (2017)
- Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood (2015)
- Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nature Genetics 46:(2) pp. 176-181. (2014)
- EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood (2013)
- Germ-line GATA2 p.THR354MET mutation in familial myelodysplastic syndrome with acquired monosomy 7 and ASXL1 mutation demonstrating rapid onset and poor survival. Haematologica (2012)