Seiamak Bahram. Professor and Director of the Unit Research 1109 
University of Strasbourg. Website
Faculty of Medicine / Institut d’Immunologie et d’Hématologie. 4 rue Kirschleger, 67085 Strasbourg Cedex, France
Reseach subject
Functional genomics of autoimmune/autoinflammatory diseases and organ/tissue grafts.
Summary
The broad, long term goal of our group – gathering clinician-scientists (rheumatologists, nephrologists and pediatric hematologists), basic/translational scientists (immunologists, geneticists, virologists), engineers (bioinformaticians, molecular biologists), post-docs, graduate students and technicians – is to study the diversity of the immune system and the immune response. Using (i) modern techniques of molecular and cell biology, (ii) highly curated patient cohorts and (iii) relevant animal models, we aim at tackling important biomedical questions with regards to immunogenetics/histocompatibility and rheumatology.
In the field of immunogenetics/histocompatibility, we are interested in high-throughput genomics of immune/inflammatory diseases and transplantation, with a strong focus on MHC-I molecules and their interaction with a model virus (BK virus) in transplanted patients. In the field of rheumatology, we are studying the role of the innate immune response in the disease pathophysiology using patient samples and animal models. Finally, the group is complemented by a multi-technology (Illumina and ThermoFisher Scientific) next-generation sequencing platform.
Publications
- Carapito R, Jung N, Kwemou M, Untrau M, Michel S, Pichot A, Giacometti G, Macquin C, Ilias W, Morlon A, Kotova I, Apostolova P, Schmitt-Graeff A, Cesbron A, Gagne K, Oudshoorn M, van der Holt B, Labalette M, Spierings E, Picard C, Loiseau P, Tamouza R, Toubert A, Parissiadis A, Dubois V, Lafarge X, Maumy-Bertrand M, Bertrand F, Vago L, Ciceri F, Paillard C, Querol S, Sierra J, Fleischhauer K, Nagler A, Labopin M, Inoko H, von dem Borne PA, Kuball JH, Ota M, Katsuyama Y, Michallet M, Lioure B, Peffault de Latour R, Blaise D, Cornelissen JJ, Yakoub-Agha I, Claas F, Moreau P, Milpied N, Charron D, Mohty M, Zeiser R, Socié G, Bahram S. (2016) Matching for the non-conventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD. Blood. Aug 22. pii: blood-2016-05-719070.
- Carapito R, Goldenberg A, Paul N, Pichot A, David A, Hamel A, Dumant-Forest C, Leroux J, Ory B, Isidor B, Bahram S. (2016) Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. Eur J Hum Genet. 2016 Jul 6. doi: 10.1038/ejhg.2016.84.
- Alsaleh G, Nehmar R, Blüml S, Schleiss C, Ostermann E, Dillenseger JP, Sayeh A, Choquet P, Dembele D, Francois A, Salmon JH, Paul N, Schabbauer G, Bierry G, Meyer A, Gottenberg JE, Haas G, Pfeffer S, Vallat L, Sibilia J, Bahram S, Georgel P. (2016) Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli. Arthritis Rheumatol. 68(8):1839-48.
- Philippe, L, G Alsaleh, A Pichot, E Ostermann, G Zuber, B Frisch, J Sibilia, S Pfeffer, S Bahram, D Wachsmann & P Georgel (2013). MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Ann Rheum Dis 72(6): 1071-1079.
- Vallat L, Kemper CA, Jung N, Maumy-Bertrand M, Bertrand F, Meyer N, Pocheville A, Fisher JW 3rd, Gribben JG, Bahram S. Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2013 110(2):459-64.
