Zoltán Prohászka. Head of Laboratory 
Semmelweis University. Website
Faculty of Medicine. 3rd Department of Medicine. H-1125 Budapest, Kutvolgyi ut 4
Reseach subject
Complement system, complement related and complement mediated diseases
Summary
The research group has long lasting interest and previous research activities in the studies of complement system, its related diseases including atypical hemolytic uremic syndrome, other forms of thrombotic microangiopathies, C3-glomerulopathies and complement deficiencies, and characterization of autoantibody formation and epitope analysis against complement regulator Factor H. The laboratory of the PI established complex diagnostics for all subgroups of TMA patients in 2007, and provided this service for more than 140 patients in the last years. Diagnostic activity includes full complement protein, activity, autoantibody determinations and genetic analysis of complement factors, regulators and related genes. Multiple patients with aHUS (several of them anti-FH antibody positive) and patients with autoimmune TTP were diagnosed and characterized for complement parameters, ADAMTS13 activity, autoantibody levels and genetic analysis. These patient cohorts form the basis of ongoing research aims on pathogenesis, diagnostics and related clinical studies.
Publications
- Prohászka Z, Nilsson B, Frazer-Abel A, Kirschfink M. Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control. Immunobiology. 2016 Nov;221(11):1247-58. doi: 10.1016/j.imbio.2016.06.008. Review. PubMed PMID: 27475991.
- Mikes B, Sinkovits G, Farkas P, Csuka D, Rázsó K, Réti M, Radványi G, Demeter J, Prohászka Z. Carboxiterminal pro-endothelin-1 as an endothelial cell biomarker in thrombotic thrombocytopenic purpura. Thromb Haemost. 2016 May 2;115(5):1034-43. doi: 10.1160/TH15-07-0564. PubMed PMID: 26763086.
- Szarvas N, Szilágyi Á, Csuka D, Takács B, Rusai K, Müller T, Arbeiter K, Réti M, Haris Á, Wagner L, Török S, Kelen K, Szabó AJ, Reusz GS, Morgan BP, Prohászka Z. Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome. Mol Immunol. 2016 Mar;71:10-22. doi: 10.1016/j.molimm.2016.01.003. PubMed PMID: 26826462.
- Szilágyi A, Kiss N, Bereczki C, Tálosi G, Rácz K, Túri S, Györke Z, Simon E, Horváth E, Kelen K, Reusz GS, Szabó AJ, Tulassay T, Prohászka Z. The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome. Nephrol Dial Transplant. 2013 Sep;28(9):2237-45. doi: 10.1093/ndt/gft198. PubMed PMID: 23787556.
- Réti M, Farkas P, Csuka D, Rázsó K, Schlammadinger Á, Udvardy ML, Madách K, Domján G, Bereczki C, Reusz GS, Szabó AJ, Prohászka Z. Complement activation in thrombotic thrombocytopenic purpura. J Thromb Haemost. 2012 May;10(5):791-8. doi: 10.1111/j.1538-7836.2012.04674.x. PubMed PMID: 22372946.