Andre Fischer. Professor (W3), Speaker of the German Center for Neurodegenerative Diseases (DZNE) Goettingen site in the Helmholtz Society 
University Medical Center of Göttingen. Website
German Center for Neurodegenerative Diseases (DZNE). Systems Medicine and Epigenetics in Neurodegenerative Diseases. Von Siebold Str 3A, Göttingen.
Reseach subject
Neuroepigenetics, Neurodegeneration, Neuropsychiatric Diseases
Summary
Our research is focused on the role of epigenetic gene-expression in the central nervous system. We aim to decipher transcriptional networks in order to understand the mechanisms that underlie brain function in health and diseases. Our specific focus are neuropsychiatric diseases such as depression, anxiety, schizophrenia and neurodegenerative diseases such as Alzheimer’s disease. To this end, we combine molecular and behavioral work in mice with the analysis of human tissue and body fluids using cutting edge molecular tools including next-generation sequencing and computational modeling.
Publications
- Bahari-Javan, S., Varbanov, H., Halder, R., Benito, E., Kaurani, L. Burkhardt, S. Anderson-Schmidt, H. Anghelescu, I. Budde, M. Stilling,R.M., Costa, J. Dietrich D., Figge, C., Folkerts, H., Gade, K., Heilbronner, U., Koller, M. Konrad, C., Nussbeck, S.Y., Scherk, H., Spitze, C., Stierl, S., Stöckel, J. Thiel, J. Hagen, M., Zimmermann, J., Zitzelsberger, A., Schulz, A., Schmitt, A., Delalls, I., Falkai, P., Schulze, T.G. Dityatev, A., Sananbenesi, F., (shared last author), Fischer, A. Hdac1 as a target for individualized therapy of schizophrenia patients. PNAS, in press
- Benito, E. Urbanke, U., Ramachandran, B., Barth, J. Halder, R., Awasthi, A. Jain, G., Capece, V., Burkhardt, S., Navarro-Sala, M. Nagarajan, N, Schütz, AL., Johnsen, SA. Bonn, SA Lührmann, R., Dean, C., Fischer, A. HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation, (2015) 125(9):3572-84
- Stilling, R.M., Rönicke, R. , Benito, E., Urbanke, H. Capece, V., Burkhardt, S. Bahari-Javan, S., Barth, J., Sananbenesi, F., Schütz, A.L., Dyczkowski, J., Martinez-hernandez, a., kerimoglu, c., dent, S.Y.R., Bonn, S., Reymann, K.G., Fischer. A. K-lysine acetyltransferase 2a regulates a hippocampal gene-expression network linked to memory formation. EMBO J. (2014) 33, 17, 1912-1927
- Govindarajan N., Rao P., Burkhardt S., Sananbenesi F., Schlüter OM., Bradke F., Lu J., Fischer A. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease. EMBO Molecular Medicine, 2013, 5,1: 52-63
- Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R.C., Cota, P., Wittnam,JL., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhoffer, M., Farinelli, L., Chen, W., Fischer, A. Altered histone H4 lysine 12 acetylation is associated with age-dependent memory impairment in mice. Science, 328; 753, 2010