Eduardo Soriano García. Professor of Cell Biology 
University of Barcelona. Website1 Website2
Faculty of Biology. Department of Cell Biology, Physiology and Immunology. Avda. Diagonal, 643. Edifici Prevosti, 1r pis. 08028 Barcelona
Reseach subject
The Armcx Genomic Cluster in Normal and Pathological Conditions; SNARE Proteins: Development and Therapeutic Targets for Axonal Regeneration and Cancer; Reelin, Neural Plasticity, Psychiatric disorders and Alzheimer Disease; Novel genetic approaches to AD pathogenesis; Rol of the Septohipocampal Pathway in AD pathonenesis
Summary
Developmental Neurobiology: Our research focuses on the identification of genes and signaling pathways that govern the development of the cerebral cortex. In particular, we study the molecular factors that regulate neural migration and the formation of specific neural connections. Major efforts are devoted to determining the role of new genes in these events, by using in vitro cell technologies and murine animal models generated in the laboratory (conditional transgenics and knock-outs). We also dissect the intracellular cascades activated by guidance molecules during neural development (kinases, adaptors, and proteins regulating exocytosis). Finally, we use several experimental approaches, including neural transplantation and genetic engineering of cell lines expressing genes with axogenic properties, to promote axonal regeneration of damaged, neural axotomized connections.
Neuronal Plasticity, Regeneration and Neurodegeneration: Adult neurogenesis and synaptic plasticity are neural plasticity processes essential for cognitive functions and learning. We are exploring the impact of manipulating key developmental genes (eg., Reelin) in adult plasticity: We also investigate whether these plasticity molecules ameliorate the structural, physiological and cognitive deficits associated to neurodegenerative diseases, with focuss on Alzheimer Diseases. We are also interested in determining the role of somatic genomic wiring in the pathogenesis of neurological diseases.
Publications
- Teixeira CM, Kron MM, Masachs N, Zhang H, Lagace DC, Martinez A, Reillo I, Duan X, Bosch C, Pujadas L, Brunso L, Song H, Eisch AJ, Borrell V, Howell BW, Parent JM, Soriano E. Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus. J Neuroscience (2012) 32:12051-65.
- López-Doménech G, Serrat R, Mirra S, D’Aniello S, Somorjai I, Abad A, Vitureira N, García-Arumí E, Alonso MT, Rodriguez-Prados M, Burgaya F, Andreu AL, García-Sancho J, Trullas R, Garcia-Fernàndez J, Soriano E. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. Nature Communications. (2012). doi: 10.1038/ncomms1829.
- Parcerisas A, Rubio SE, Muhaisen A, Gómez-Ramos A, Pujadas L, Puiggros M, Rossi D, Ureña J, Burgaya F, Pascual M, Torrents D, Rábano A, Avila J, Soriano E. Somatic signature of brain-specific single nucleotide variations in sporadic Alzheimer’s disease. J Alzheimers Disease. (2014); 42(4):1357-82.
- Pujadas L, Rossi D, Andrés R, Teixeira CM, Serra-Vidal B, Parcerisas A, Maldonado R, Giralt E, Carulla N, Soriano E. Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease. Nature Communications. (2014). doi: 10.1038/ncomms4443.
- Ros O, Cotrufo T, Martínez-Mármol R, Soriano E. Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1. J Neuroscience. (2015); 35(13):5156-70.