Victor Moreno Aguado. Professor of Preventive Medicine 
University of Barcelona. Website
Catalan Institute of Oncology (ICO). Bellvitge Biomedical Research Institute (IDIBELL). Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP). Faculty of Medicine. Department of Clinical Sciences. Av. Gran Vía 199-203. 08908, L’Hospitalet de Llobregat, Barcelona, Spain
Reseach subject
Genetic and molecular epidemiology studies for cancer prevention
Summary
Dr Victor Moreno’s research area is cancer prevention, with a special interest in colorectal cancer (CRC). Using the bioinformatics tools to study genetic and molecular epidemiology, the group is aiming to identify biomarkers and develop risk models useful for population stratification strategies that should lead to improved screening and therapeutics. For this purpose, patient’s data and samples are analyzed in case-control studies and clinical cohorts. The whole-genome expression data, SNPs, CNVs, mosaicism, methylation, miRNAs and somatic mutations from exome sequencing are being assessed. Dr Victor Moreno’s group has designed and conducted several big case-control studies such as MCC-Spain (CIBEResp) and COLONOMICS (www.colonomics.org). This has generated relevant outputs about CRC carcinogenesis and its environmental and genetic risk factors, empowering the group’s further research in recent wide national (COLSCREEN, CRIPREV) and international studies (Motricolor H2020, FIGI R01). Additionally, the role of genes in diverse pathways and in disease susceptibility is being analyzed, either with a candidate gene approach, or contributing to the validation of GWAS hits within international consortia GECCO/CORECT (US) and EUCONGENE (EU). The long follow-up of the case-series and well annotated clinical data has allowed further studies of prognostic biomarkers based on the molecular expression profiles.
Publications
- Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study. Ibáñez-Sanz G, Díez-Villanueva A, Alonso MH, Rodríguez-Moranta F, Pérez-Gómez B, Bustamante M, Martin V, Llorca J, Amiano P, Ardanaz E, Tardón A, Jiménez-Moleón JJ, Peiró R, Alguacil J, Navarro C, Guinó E, Binefa G, Navarro PF, Espinosa A, Dávila-Batista V, Molina AJ, Palazuelos C, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, Moreno V. Sci Rep. 2017 Feb 24;7:43263. doi: 10.1038/srep43263.
- Mutanome and expression of immune response genes in microsatellite stable colon cancer. Sanz-Pamplona R, Gil-Hoyos R, López-Doriga A, Alonso MH, Aussó S, Molleví DG, Santos C, Sanjuán X, Salazar R, Alemany R, Moreno V. Oncotarget. 2016 Apr 5;7(14):17711-25. doi: 10.18632/oncotarget.7293.
- Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. Sanz-Pamplona R, Lopez-Doriga A, Paré-Brunet L, Lázaro K, Bellido F, Alonso MH, Aussó S, Guinó E, Beltrán S, Castro-Giner F, Gut M, Sanjuan X, Closa A, Cordero D, Morón-Duran FD, Soriano A, Salazar R, Valle L, Moreno V. Clin Cancer Res. 2015 Oct 15;21(20):4709-18. doi: 10.1158/1078-0432.CCR-15-0159.
- Large differences in global transcriptional regulatory programs of normal and tumor colon cells. Cordero D, Solé X, Crous-Bou M, Sanz-Pamplona R, Paré-Brunet L, Guinó E, Olivares D, Berenguer A, Santos C, Salazar R, Biondo S, Moreno V. BMC Cancer. 2014 Sep 24;14:708. doi: 10.1186/1471-2407-14-708.
- Discovery and validation of new potential biomarkers for early detection of colon cancer. Solé X, Crous-Bou M, Cordero D, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R, Moreno V. PLoS One. 2014 Sep 12;9(9):e106748. doi: 10.1371/journal.pone.0106748